Portraits of scientist David Baker, Nobel laureate and UW professor, for Seattle Met
October 16, 2024

David Baker is the director of the Institute for Protein Design, a Howard Hughes Medical Institute Investigator, a professor of biochemistry, and an adjunct professor of genome sciences, bioengineering, chemical engineering, computer science, and physics at the University of Washington, seen here in his lab in Seattle, Washington, USA, on Wed., Sept. 11, 2024. Baker's research group focuses on the design of synthetic nanoparticles including proteins and peptides.
David Baker is the director of the Institute for Protein Design, a Howard Hughes Medical Institute Investigator, a professor of biochemistry, and an adjunct professor of genome sciences, bioengineering, chemical engineering, computer science, and physics at the University of Washington, seen here in his lab in Seattle, Washington, USA, on Wed., Sept. 11, 2024. Baker's research group focuses on the design of synthetic nanoparticles including proteins and peptides.
A model of a computationally designed peptide nanoparticle rests on a desk in an Institute for Protein Design lab at the University of Washington in Seattle, Washington, USA, on Wed., Sept. 11, 2024. The two sides of the particle (orange and blue) have opposite chirality or handedness in their design, yielding a symmetric design. Most life on earth has left-handed chirality, and human bodies are designed to break down left-handed particles that enter the body. By creating a medicine-delivery particle such as this with half right-handed chirality, it makes the medicine more difficult for a body to break it down, hopefully allowing for medicine that has a longer therapeutic effect in a human. David Baker is the director of the Institute for Protein Design, a Howard Hughes Medical Institute Investigator, a professor of biochemistry, and an adjunct professor of genome sciences, bioengineering, chemical engineering, computer science, and physics at the University of Washington. Baker's research group focuses on the design of synthetic nanoparticles including proteins and peptides.
A model of a designed protein nanoparticle rests on a desk in an Institute for Protein Design lab at the University of Washington in Seattle, Washington, USA, on Wed., Sept. 11, 2024. Each color is a unique protein and each bump is an individual atom. The technology used in getting the proteins to form together in this symmetric protein structure allows the creation of medicines and vaccines. David Baker is the director of the Institute for Protein Design, a Howard Hughes Medical Institute Investigator, a professor of biochemistry, and an adjunct professor of genome sciences, bioengineering, chemical engineering, computer science, and physics at the University of Washington. Baker's research group focuses on the design of synthetic nanoparticles including proteins and peptides.
David Baker is the director of the Institute for Protein Design, a Howard Hughes Medical Institute Investigator, a professor of biochemistry, and an adjunct professor of genome sciences, bioengineering, chemical engineering, computer science, and physics at the University of Washington, seen here in his lab in Seattle, Washington, USA, on Wed., Sept. 11, 2024. Baker's research group focuses on the design of synthetic nanoparticles including proteins and peptides.
David Baker is the director of the Institute for Protein Design, a Howard Hughes Medical Institute Investigator, a professor of biochemistry, and an adjunct professor of genome sciences, bioengineering, chemical engineering, computer science, and physics at the University of Washington, seen here in his lab in Seattle, Washington, USA, on Wed., Sept. 11, 2024. Baker's research group focuses on the design of synthetic nanoparticles including proteins and peptides.
David Baker is the director of the Institute for Protein Design, a Howard Hughes Medical Institute Investigator, a professor of biochemistry, and an adjunct professor of genome sciences, bioengineering, chemical engineering, computer science, and physics at the University of Washington, seen here in his lab in Seattle, Washington, USA, on Wed., Sept. 11, 2024. Here, he is holding a model of a designed protein nanoparticle. Each color is a unique protein and each bump is an individual atom. The technology used in getting the proteins to form together in this symmetric protein structure allows the creation of medicines and vaccines. Baker's research group focuses on the design of synthetic nanoparticles including proteins and peptides.
David Baker is the director of the Institute for Protein Design, a Howard Hughes Medical Institute Investigator, a professor of biochemistry, and an adjunct professor of genome sciences, bioengineering, chemical engineering, computer science, and physics at the University of Washington, seen here in his lab in Seattle, Washington, USA, on Wed., Sept. 11, 2024. Baker's research group focuses on the design of synthetic nanoparticles including proteins and peptides.

More than a month ago, and weeks before the big Nobel Prize news was announced, I had a (very) few minutes with University of Washington professor David Baker, for local magazine Seattle Met. Then, last week, the Nobel committee announced that Baker was one of the recipients of the 2024 Nobel Prize in Chemistry for his work on computational protein design. After the few minutes with Dr. Baker, I spent a little time photographing his 3D-printed models of synthetic proteins and other structures, the designs of which have promising potential in the field of medicine.

A big thanks to Nate at Seattle Met for the call on this assignment, which was my first for the publication. Here’s a link to the interview.

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